dbDNA Markets
The genetic medicines market has grown dramatically in recent years, with advanced therapies driving transformational improvements in the treatment of devastating diseases.
Our versatile dbDNA™ vector is well suited for application in any state-of-the-art therapy area that is fundamentally based on DNA.
mRNA Overview
dbDNA™ is the optimal template for mRNA production via in vitro transcription (IVT). Our platform enables rapid, scalable development and GMP production without the need for a Master Cell Bank, and a reduced quantity of DNA is required for equivalent yields.
Find out more about DNA supply for mRNA production
Services
- Off-the-shelf reporter genes for initial testing
- Custom development and production of high purity dbDNA™ templates for IVT
- Linearisation of bulk dbDNA™ for IVT
- Rapid response platform support and library generation
- Regulatory support service
- Available catalogue products: luciferase and GFP reporters
Resources
Find out more about our work and research into mRNA in our knowledge centre
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Lentivirus Overview
dbDNA™ is an alternative to plasmid DNA in lentivirus production by transient transfection, requiring less DNA material for at least equivalent infectious titres.
Off-the-shelf catalogue products
Get started quickly with off-the-shelf constructs available for you to test in your Lentivirus process:
Lenti Constructs
- VSV-G
- eGFP transgene
- Rev
- GagPol
Services
- Off-the-shelf packaging dbDNA™ and reporter transgene
- Custom development and GMP production of dbDNA™ constructs for transient transfection
- Regulatory support service
- Available catalogue products: helper dbDNA™ and GFP reporter
Get in touch
For more information on how we can help with your project, please get in touch.
Contact usResources
Find out more about our work and research into lentiviruses in our knowledge centre
Read our research
AAV Overview
dbDNA™ is substitutable for plasmid DNA in AAV (adeno-associated virus) production by transient transfection, typically requiring less DNA material for equivalent infectious titres, and eliminating packaging of bacterial sequences.
Replacing plasmid DNA with enzymatically produced dbDNA in your AAV production eliminates many issues around complex or unstable sequences, alongside improved speed to manufacture, safety and scalability.
Find out more about DNA supply for AAV production
Access the enzymatic DNA for AAV production info sheet
Off-the-shelf catalogue products
Get started quickly with off-the-shelf constructs available for you to test in your AAV process:
AAV Constructs
- CMV-Lux-2A-eGFP Transgene
- Rep2Cap2
- AdHelper
Services
- Off-the-shelf catalogue products for initial evaluation including repcap and helper dbDNA™
- Conduct a feasibility assessment with the supply of mg of dbDNA of your custom sequence of interest. This can be a quick and easy way to assess your product in the dbDNA platform.
- Toxicology and cGMP material supply. Flexible supply and development to meet your scale and timeline.
Get in touch
For more information on how we can help with your project, please get in touch
Contact usResources
Find out more about our work and research into AAV in our knowledge centre
Read our research
Genome editing Overview
dbDNA™ can be used as a high-purity linear reagent for genome editing applications, including as a homology directed repair (HDR) template for ex vivo cell therapy and to deliver transposons.
Services
- Off-the-shelf HDR reporter gene templates for initial evaluation
- Custom development and GMP production for genome editing
- Available catalogue products: HDR template with GFP reporter
Get in touch
For more information on how we can help with your project, please get in touch
Contact usResources
Find out more about our work and research into genome editing in our knowledge centre
Read our research
DNA vaccines Overview
dbDNA™ is an optimal vector for DNA vaccines. dbDNA™ is compatible with a wide range of gene delivery technologies and shows equivalent efficacy to plasmid DNA with a lower dose.
Services
- Off-the-shelf reporter genes for evaluation
- Custom dbDNA™ development and GMP production for use as a DNA vaccine
- Available catalogue products: multiple reporters including GFP, luciferase and SeAP with multiple promoters, plus DNA vaccine constructs
Get in touch
For more information on how we can help with your project, please get in touch
Contact usResources
Find out more about our work and research into DNA vaccines in our knowledge centre
Read our research
Non-viral gene therapy Overview
dbDNA™ is an optimal vector for non-viral gene therapy, containing no immunogenic bacterial sequences and with an improved expression profile versus multiple DNA formats.
Services
- Off-the-shelf reporter genes for evaluation
- Custom dbDNA™ development and GMP production
- Available catalogue products: multiple reporters including GFP, luciferase and SeAP with multiple promoters
Get in touch
For more information on how we can help with your project, please get in touch
Contact usResources
Find out more about our work and research into non-viral gene therapies in our knowledge centre
Read our researchContact Us
We’d like to hear from you
For more information on how our dbDNA™ platform could help advance your project, please contact us.
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