dbDNA™ Markets

The genetic medicines market has grown dramatically in recent years, with advanced therapies driving transformational improvements in the treatment of devastating diseases.

Our versatile dbDNA™ vector is well suited for application in any state-of-the-art therapy area that is fundamentally based on DNA.

mRNA Overview

dbDNA™ is the optimal template for mRNA production via in vitro transcription (IVT). Our platform enables rapid, scalable development and GMP production without the need for a Master Cell Bank, and a reduced quantity of DNA is required for equivalent yields.

Services

  • Off-the-shelf reporter genes for initial testing
  • Custom development and production of high purity dbDNA™ templates for IVT
  • Linearisation of bulk dbDNA™ for IVT
  • Rapid response platform support and library generation
  • Regulatory support service
  • Available catalogue products: luciferase and GFP reporters
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For more information on our mRNA and how we can help, please get in touch.

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Resources

Find out more about our work and research into mRNA in our knowledge centre

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Lentivirus Overview

dbDNA™ is an alternative to plasmid DNA in lentivirus production by transient transfection, requiring less DNA material for at least equivalent infectious titres.

Services

  • Off-the-shelf packaging dbDNA™ and reporter transgene
  • Custom development and GMP production of dbDNA™ constructs for transient transfection
  • Regulatory support service
  • Available catalogue products: helper dbDNA™ and GFP reporter
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For more information on how we can help with your project, please get in touch.

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Resources

Find out more about our work and research into lentiviruses in our knowledge centre

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AAV Overview

dbDNA™ is substitutable for plasmid DNA in AAV (adeno-associated virus) production by transient transfection, typically requiring less DNA material for equivalent infectious titres, and eliminating packaging of bacterial sequences.

Services

  • dbDNA™ production services are provided by Touchlight AAV
  • Available catalogue products: repcap & and helper dbDNA™
  • Please visit the website: www.touchlightaav.com
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For more information on how we can help with your project, please get in touch

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Resources

Find out more about our work and research into AAV in our knowledge centre

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Genome editing Overview

dbDNA™ can be used as a high-purity linear reagent for genome editing applications, including as a homology directed repair (HDR) template for ex vivo cell therapy and to deliver transposons.

Services

  • Off-the-shelf HDR reporter gene templates for initial evaluation
  • Custom development and GMP production for genome editing
  • Available catalogue products: HDR template with GFP reporter
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For more information on how we can help with your project, please get in touch

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Resources

Find out more about our work and research into genome editing in our knowledge centre

Read our research

DNA vaccines Overview

dbDNA™ is an optimal vector for DNA vaccines. dbDNA™ is compatible with a wide range of gene delivery technologies and shows equivalent efficacy to plasmid DNA with a lower dose.

Services

  • Off-the-shelf reporter genes for evaluation
  • Custom dbDNA™ development and GMP production for use as a DNA vaccine
  • Available catalogue products: multiple reporters including GFP, luciferase and SeAP with multiple promoters, plus DNA vaccine constructs
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For more information on how we can help with your project, please get in touch

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Resources

Find out more about our work and research into DNA vaccines in our knowledge centre

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Non-viral gene therapy Overview

dbDNA™ is an optimal vector for non-viral gene therapy, containing no immunogenic bacterial sequences and with an improved expression profile versus multiple DNA formats.

Services

  • Off-the-shelf reporter genes for evaluation
  • Custom dbDNA™ development and GMP production
  • Available catalogue products: multiple reporters including GFP, luciferase and SeAP with multiple promoters
Get in touch

For more information on how we can help with your project, please get in touch

Contact us
Resources

Find out more about our work and research into non-viral gene therapies in our knowledge centre

Read our research
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We’d like to hear from you

For more information on how our dbDNA™ platform could help advance your project, please contact us.

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