The making of DNA

Enabling the genetic medicine revolution with our unique dbDNA™ technology.

How we make DNA
Platform Technology

dbDNA™:
Powering the genetic medicine revolution

Our novel, synthetic DNA vector, “doggybone” or dbDNA™, and its enzymatic production, enable us to make DNA at the speed, scale and purity necessary to support the rapid growth of genetic medicines.

Doggybone DNA animation
Enzyme

DNA made using enzymes

We are disrupting the decades-old technology of DNA production, moving away from restrictive biological approaches to instead use a synthetic DNA vector.

Our platform technology
Rapid icon
Rapid

Enzymatic manufacturing enables multi-gram GMP DNA production in weeks rather than months

Scalable icon
Scalable

Manufactured using benchtop equipment with a significantly smaller footprint than fermentation-based production

Mobile icon
Mobile

dbDNA™ technology is highly portable and amenable to technology transfer

Optimal vector icon
Optimal vector

dbDNA™ can encode long, complex, unstable sequences, eliminates bacterial sequences, and has a strong expression profile

Addressing a broad market

Our versatile dbDNA™ technology is being applied across the genetic medicine industry.

mRNA icon

mRNA

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Lentivirus

Lentivirus

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AAV icon

AAV

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Genome editing icon

Genome editing

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DNA vaccines icon

DNA vaccines

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Non viral gene therapy

Non-viral gene therapy

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Our Services

What can we do for you?

We offer a range of services to support development and commercialisation of the next generation of DNA products.

Pre-clinical services
Pre-clinical services
  • Catalogue products
  • Molecular biology
  • Custom research grade
  • Toxicology materials
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GMP Supply
GMP supply
  • GMP dbDNA™ (critical starting materials)
  • GMP dbDNA™ (drug substance)
  • Commercial supply / on-site supply
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Development Services
Development Services
  • Analytical development
  • Scale up development
  • Formulation
  • Stability
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Regulatory Support
Regulatory support
  • Regulatory support
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Our facilities

Headquartered in Hampton

Take a tour of our stunning buildings and state-of-the-art dbDNA™ manufacturing facilities.

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Our programs and partners

Work with us to develop the next generation of DNA products

We are working in collaboration with esteemed partners, to leverage dbDNA™ in areas where it may offer unique or improved therapies or devices.

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Knowledge Centre

Webinar DNA technology
Webinar – Strategies for commercialising a novel enzymatic DNA technology
Read more
mRNA production info sheet header
Info sheet – Enzymatic DNA for mRNA production
Download
MDPI publication - SARS CoV 2 doggybone DNA
MDPI – SARS-CoV-2 Doggybone DNA Vaccine Produces Cross-Variant Neutralizing Antibodies and Is Protective in a COVID-19 Animal Model
Read Article
White paper on harnessing therapeutic potential
Lisa Caproni

Dr Lisa Caproni

White paper – Harnessing the therapeutic potential of DNA vaccines
Read Article
Genome editing webinar
Webinar – How dbDNA resolves the challenges of plasmid DNA in genome editing
Read Article
Nature publication
Nature Gene Therapy – Enzymatically amplified linear dbDNA as a rapid and scalable solution to lentiviral vector manufacturing
Read Article
Knowledge centre

News

06 July 2022

Touchlight signs patent license agreement with Pfizer for the use of dbDNA for the manufacture of mRNA-based vaccines, therapeutics and gene therapies

Pfizer and Touchlight agree to patent license for Pfizer to utilise rapid, scalable, enzymatic doggybone DNA (dbDNA) in Pfizer’s clinical and commercial manufacture of its mRNA vaccines, therapeutics, and gene...

01 March 2022

Touchlight and Versameb announce GMP manufacturing supply agreement

Versameb moves forward with its lead asset towards clinical development with an Innovative synthetic doggybone DNA technology which increases quality and yield of mRNA therapeutics production Hampton, UK, Basel, Switzerland...

08 February 2022

AskBio and Touchlight Restructure Joint Venture

Asklepios BioPharmaceutical, Inc. (AskBio), a gene therapy company wholly owned and independently operated as a subsidiary of Bayer AG, and Touchlight, a biotechnology company pioneering enzymatic DNA production, have announced...
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We'd like to hear from you

For more information on how our dbDNA™ technology could help advance your project, please contact us.

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