1 March 2022

Touchlight and Versameb announce GMP manufacturing supply agreement

  • Versameb moves forward with its lead asset towards clinical development with an Innovative synthetic doggybone DNA technology which increases quality and yield of mRNA therapeutics production

Hampton, UK, Basel, Switzerland – 1 March 2022 Touchlight, a biotechnology company pioneering enzymatic DNA production to enable the genetic medicine revolution, today announces a development and manufacturing pipeline agreement with Versameb AG, an innovative pre-clinical stage company focused on discovering and developing ground-breaking RNA-based therapeutics.

The agreement enables Versameb to use Touchlight’s proprietary doggybone DNA (dbDNA™) vector technology to support the development of novel mRNA-based therapeutics addressing unmet needs in urology and oncology. This includes Versameb’s lead candidate VMB-100, a potentially first-in-class regenerative treatment for Stress Urinary Incontinence (SUI), which is expected to enter clinical development in the second half of 2022.

Versameb’s proprietary VERSagile platform can both enhance the effectiveness of RNA and target multiple proteins simultaneously within a single molecule. Versameb will use Touchlight’s dbDNA technology for manufacturing and clinical supply of VMB-100 and other future pipeline products.

Touchlight’s dbDNA is a minimal, linear, double stranded, covalently closed DNA vector which is produced through an enzymatic manufacturing process. It can accommodate genes of interest of more than 20kb and is linearly scalable, making it highly adaptable to support a range of genetic medicines.

Karen Fallen, CEO, Touchlight DNA Services commented: “We are delighted to be supporting the experienced team at Versameb on the development of its product portfolio. dbDNA has shown superior yield and genetic stability compared to conventional plasmid methods in mRNA production as well as faster GMP manufacturing. Our advanced vector technology and enzymatic process will support the tremendous growth of mRNA technology as well as enabling other plasmid DNA reliant technologies to deliver beyond what is possible with current methods.”

“Genetic medicine has proven its potential and is now expected to become a key element in the toolbox of healthcare professionals. However, manufacturing processes also have to evolve, in order to overcome existing bottlenecks. Innovations, such as dbDNA, will be crucial for the advancement of the industry.”

Klaas Zuideveld, CEO of Versameb, said: “We are excited to be driving the necessary activities to take our lead asset to the clinic in the shortest possible timeframe. Working with a company such as Touchlight and to utilise dbDNA as a starting material for the production of our mRNA therapeutics assures a production process which is innovative and gives a competitive advantage. The high stability, quality and speed offered by synthetic replication of DNA, the starting material for mRNA, plays as key role in the production of Versameb’s proprietary biologically optimized VERSagile mRNA pipeline.


Access a PDF version of the ‘Touchlight and Versameb announce GMP manufacturing supply agreement’ press release here.

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About Touchlight

Touchlight is a privately-owned biotechnology company based in London, U.K., focussed on the discovery and development of DNA-based genetic medicines, including DNA vaccines and gene therapies. Touchlight has developed a novel, synthetic DNA vector known as doggybone DNA” or dbDNA™.

dbDNA is a minimal, linear, covalently closed structure, that eliminates bacterial sequences. Touchlight’s revolutionary enzymatic production platform enables unprecedented speed, scale, and the ability to target genes with a size and complexity that is impossible with current technologies.

Touchlight is applying dbDNA across advanced therapeutic modalities, both in-house and with partners. The company also provides contract manufacturing capabilities to produce dbDNA as a critical starting material for advanced therapy production through its manufacturing arm, Touchlight DNA Services.

Issued for and on behalf of Touchlight by Instinctif Partners.

For more information please contact:

Karen Fallen, Chief Executive Officer Agnes Stephens
Robin Bodicoat, Head of Marketing E: touchlight@instinctif.com
E: info@touchlight.com T: +44 20 7457 2020
T: +44 20 8481 9200